E-RIHS is a distributed Research Infrastructure (RI) including the Central Hub and many research facilities focused on preserving the world’s heritage by providing cross-cutting edge researchers, knowledge, capabilities, and infrastructures. E-RIHS is a publicly funded RI, and, therefore, it is crucial to estimate the return on investment and the ability to generate an economic and social value per countries involved. Following this accountability perspective, CSIL was selected to provide two specific analyses, i.e., a quantitative cost-benefit analysis (CBA) and a comprehensive quali-quantitative socio-economic impact assessment. The studies dedicated special attention to the impact on preventive conservation, tourism and cultural and creative industries, and E-RIHS contribution to the knowledge, protection, valorisation and management of heritage.